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CRL E3 Complexes: Assembled for Destruction
Liu Xiangyuan, Hu Hongli, Ouyang Huafang, Gao Daming*
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, Shanghai 200031, China
Abstract: Cullin-Ring Ligase (CRL) refers to a large family of ubiquitin E3 ligases composed of similar architectures， including a scaffold Cullin protein， a Ring protein (Rbx1 or Rbx2)， and a substrate receptor module. Different Cullin protein decides the presence of other components in the same CRL complex. After nearly 2 decades of research efforts， much knowledge of CRL has been gained. This review is focused on giving a overlook of current understanding of functional and regulatory mechanisms of CRL complexes.
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