Notch Signaling and Its Role in Regulation of T Cell Development and Differentiation

Abstract: Mammalian Notch proteins (Notch1朜otch4) function as membrane receptors with two kinds of ligands: Jagged family (Jagged1， Jagged2) and Delta-like family (DLL1， DLL3， DLL4). Notch signaling is involved in processes of protein cleavage. The components of the signal pathway consist of some special trans-acting factors and co-activators such as mastermind-like 1 (MAML1)， which result in transcription of target genes Hes， Hey and Deltex. Notch proteins play critical role not only in early development of T cell lineage， but also in activation and proliferation of peripheral T cells， as well as in differentiation of Th subsets. Notch signaling is especially crucial for Th2 differentiation via activation of transcription factor GATA-3

CSTR: 32200.14.cjcb.2008.04.0006