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Oncolytic Vaccinia Virus Vector for Genetherapy of Cancer
Wang Shibing1,2, Chen Kan2, Kong Xiangdong2*
1Research Center, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China; 2Bio-X Center, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China
Abstract: Gene therapy has always been an important strategy for the biological treatment of tumor.Vaccinia virus has emerged as an attractive agent especially when used as an oncolytic virus vector. This review describes the use of vaccinia virus in cancer therapy as a oncolytic virus and the progress of vaccinia virus vectorbased gene therapy and its achievements in various fields.
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