E3 Ligase Activity of CHIP， a Cochaperones and Its Biological Significance

Abstract: CHIP， carboxy terminus of Hsc70 interacting protein， is a new co-chaperone with E3 ligase activity discovered recently. It had the tetratricopeptide repeat (TPR) domain at its amino terminus and could interact with chaperones， and it had E3 ligase activity with a U-box domain at its carboxy terminus. CHIP could play a E3 ligase role during a series of protein degradation to control proteins quality in the cell. The structure and ability， client substrates， biological characterization and roles in illness of CHIP were reviewed in this paper.
    

CSTR: 32200.14.cjcb.2008.04.0005