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Involvement of Phosphodiestersae Type 5 in Regulation of Smooth Muscle Function
Jian Li, Fang-Xiong Shi*
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
Abstract: Phosphodiesterase type 5 (PDE5) is a cGMP-specific PDE. As a major cGMP-hydrolyzing PDE， PDE5 regulates the development of smooth muscle relaxation and has a potential value in the fields of physiology， pathophysiology and pharmocology. Herein， regulation of PDE5 expression and activity， subcellular localization and mechanisms in smooth muscle functions are reviewed. Furthermore， the clinic applications of PDE5 mechanisms are discussed.
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