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DNA Methylation Patterns and Their Roles in Cancers
Yu You, Zhu Han, Lu Jiawei, Yao Huihui, Chen Jianming*
College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China
Abstract: With the deepening of the research on cancers， epigenetic regulation is now gaining more and more concern about its effects on the occurrence and development of cancers. DNA methylation， an important mechanism in epigenetic modifications， plays a significant role in the regulation of gene expression. In this review， DNA methylation patterns and their roles in cancers were reviewed. Additionally， DNA methylation as the bio-marker in the early diagnosis of cancers and the new strategy in the epigenetic therapy of cancers were summarized and their futures were prospected.
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