Home > Browse Issues > Vol.35 No.12
Research Advance of TET Family DNA Hydroxylase and 5-hmC in Neoplasm
Wu Yichen1,2, Ling Zhiqiang1*
1Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, China; 2School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, China
Abstract: Dysregulated DNA methylation followed by abnormal gene expression is an epigenetic feature in neoplasm. It is well known that DNA methylation is catalyzed by DNA methyltransferases， and the mutation of DNA methyltransferase gene and the aberrant expression influence the balance of DNA methylation. Recently， the enzyme for demethylating 5-methylcytosine were identified. TET (Ten-Eleven translocation) protein regulates the DNA demethylation pathway via various mechanisms. As a important intermediate product of DNA demethylation， the level of 5-hydroxymethylcytosine floats significantly in the period of tumor development. This review will detail the TET proteins from their structure， function， mechanism and introduce recent advances in researches on the relation between the biology significance of TET protein and 5-hmC regulation in various cancers. We also summarize the clinical significance of TET gene and 5-hmC in tumorigenesis and development.
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