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Roles of Non-coding RNAs in the Occurrence of Laryngeal Carcinoma and Their Clinical Significances
Li Qun1, Lu Dakai1, Cui Xiang1, Xia Tian1, Shen Zhisen2*, Guo Junming1*
1Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China; 2Department of Otorhinolaryngology, the Affiliated Lihuili Hospital
Abstract: Laryngeal carcinoma is one of the most common malignancies in human head-and-neck region. Patients with laryngeal carcinoma usually have serious troubles in swallowing， respiration and pronunciation. They suffer from pain of “hard to express”. As a result， patients’ life quality is deteriorating sharply. To improve early diagnostic， treatment and prevention of laryngeal carcinoma， characterizing its molecular mechanisms has been of major interest. With recent technical developments in next-generation sequencing， transcriptomics， bioinformatics etc.， several non-coding RNAs (ncRNAs) associated with laryngeal carcinoma have been identified. Short ncRNAs， miR-16， miR-21， miR-106b and miR-1297 are up-regulated in laryngeal carcinoma; While let-7a， miR-1， miR-24， miR-34a/c， miR-137， miR-203 and miR-206 down-regulated. Long ncRNAs， H19， HOTAIR and MALAT-1 also express aberrantly in laryngeal carcinoma. Acting as oncogenes or tumor suppressors， those ncRNAs affect cells’proliferation， invasion， metastasis and apoptosis. Therefore， ncRNAs play important roles in the occurrence， development and progress of laryngeal carcinoma. Potentially， related ncRNAs may be used as novel biomarkers in diagnosis or drug targets for anti-cancer therapeutics.
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