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Progress in the Study of Mitochondria-endoplasmic Reticulum Physical Coupling
Xue Liang, Yin Changcheng*
Department of Biophysics, School of Basic Medical Sciences, Peking University, Beijing 100191, China
Abstract: Physical contacts between mitochondria and endoplasmic reticulum， also referred as MAMs， have become an emerging issue in mitochondria research. Dozens of proteins are recruited within the contact， including mitofusion2， IP3R， grp75， PACS-2 etc.， which provide structural basis for cell signaling. Especially enriched in phospholipid synthases， MAMs are believed to be fundamental to lipid metabolism. It also has been recognized that mitochondria uptake Ca2+ preferentially from the microdomains of elevated Ca2+ concentration that exist around these contacts. Besides， it has been found that some cellular processes such as apoptosis are related with mitochondria-endoplasmic reticulum physical coupling.
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