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Decisive Effects of Oocytes on the Ovulatory Process in the Mammalian Ovary
Luo Qianping1, Wu Yanqing1, Wu Lixiang2, Zhang Zhenghong1, Wang Zhengchao1*
1Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University,Fuzhou 350007, China; 2Fujian Provincial Maternity and Child Care Center, Fuzhou 350001, China
Abstract: Ovulation is a complex regulating process in the mammalian ovary. This important physiological process includes oocytes released from the ovary with follicle ruptures after the oocyte maturation. Follicular cells sense the ovulatory stimulus and induce the resumption of meiosis and subsequent release of oocytes. Paracrine between the oocyte and its surrounding granulosa cells plays a critical role in this process， and the oocyte has the decisive effect on its release. Previously， we have described the regulatory effect of granulosa cells on ovarian ovulation in mammals. In the present paper， we clarify the decisive effects of oocytes on the ovulatory process in mammalian ovaries from the perspective of the oocyte development and its regulation， in order to further understand ovulation and provide the important research direction and theoretical basis for the treatment of ovarian diseases， such as infertility.
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