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The Clinical Significance of DcR3 Expression in Papillary Thyroid Carcinoma
Lai Yongfeng1, Xing Ping1, Xu Jinye1, Quan Mingming2, Jin Xiaoyan2, Yang Jingjin2,3, Zhang Qiang2, Liang Yong2,3*
1The First Afiliated Hospital,Wenzhou Medical University, Wenzhou 325000, China; 2Department of oncologic surgery, the Afiliated Municipal Hospital, TaizhouUniversity, Taizhou 318000, China; 3Medical School, Taizhou Univer
Abstract: To explore the expression of DcR3 and it’s clinical significance in papillary thyroid carcinoma， the expression of DcR3 mRNA in papillary thyroid carcinoma (n=50) and adjacent normal thyroid tissue (n=50) was detected by RT-PCR， and DcR3 protein was detected by Western blot and immunohistochemistry. RT-PCR result showed that the expression of DcR3 mRNA in papillary thyroid carcinoma tissue was higher than normal thyroid tissue (P<0.05); Western blot and immununohistochemistry (IHC) results showed DcR3 protein expressed higher in papillary thyroid carcinoma (P<0.05). DcR3 overexpressed both in mRNA and protein level in papillary thyroid carcinoma， it suggests that DcR3 may promote the formation and progress of papillary thyroid carcinoma.
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