Home > Browse Issues > Vol.30 No.4
The Progress in Na+/H+ Exchanger
Jun-Ying Zeng1,2, Shao-Xun Tang1,2, Zhi-Hong Sun1,2, Zhi-Liang Tan2*
1Graduate School of the Chinese Academy of Science, Beijing 100039, China; 2Institute of Subtropical Agriculture, Chinese Academy of Science, Changsha 410125, China
Abstract: In mammalian eukaryotic cells， the Na exchanger (NHE) is a family of membrane protein that regulates ions fluxes across membranes， which regulates intracellular pH homeostasis by extruding one intracellular proton in exchange for one extracellular sodium. It also plays a key role in the cellular functions including volume regulation， migration， proliferation， differentiation and apoptosis， which involved in a variety of complex physiological and pathological events. To date， The NHE family consists of 9 known isoforms， NHE1-NHE9， which have homology structure and different tissue distribution. To study the topology， function and gene expression of NHE， it may provide a new way on nutrition regulation， immune enhancement and treating for diseases of human and animal.
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