Advances on the FoxA Transcription Factors in Liver Development

Uyunbilig Borjigin¹, Gu Tingyu², Lü Xiaowen², Xu Chenhuan², He Zhiying³, Wang Xin^1,2*

1The Key Laboratory of Mammalian Reproductive Biology and Biotechnology, Ministry of Education, Inner Mongolia University, Hohhot 010021, China; 2The Laboratory of Cellular and Molecular Biology, Shanghai Institute of Cell Biology and Biochemistry, Chines

Abstract: FoxA proteins are subfamily of winged helix/forkhead box (Fox) transcription factors. Its three members， FoxA1， FoxA2 and FoxA3， have been found to play important roles in mammalian early embryo development， organogenesis， metabolism and homeostasis in the adult. FoxA proteins are key transcriptional regulators in liver development and play “pioneer factor’’ in liver specific genes transcription. This review summarizes the recent research of FoxA transcription factors in the regulation of liver development.

CSTR: 32200.14.cjcb.2013.10.0018