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Update of Mitochondrial Mechanism Under the Diseases Related to Oxidative Stress
Gong Qingli, Li Xue, Lu Yan*
Department of Dermatology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
Abstract: Oxidative stress is defined as the imbalance between the generation of reactive oxygen species (ROS) or reactive nitrogen species (RNS) and antioxidant defense system， which is implicated in the pathogenesis of a variety of disorders， including neurodegenerative diseases， cancer and inflammatory diseases. Mitochondria， as the center of cell metabolism， are the main targets. Lipids， proteins and nucleic acids within mitochondria are significantly damaged by oxidative stress， resulting in changes of mitochondrial structures and functions. This review focuses on the update of mitochondrial changes in the above mentioned diseases related to oxidative stress.
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