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Research Progress of HIV-1 Integrase and Its Inhibitors
Shen Xuebin1,2, Ye Jian1, Yang Lili1,2, Chen Huan3, Lou Yijia2, Samson A. Chow1,4*
1Zhejiang-California International NanoSystems Institute, Zhejiang University, Hangzhou 310029, China; 2Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, Zhejiang University, Zhejiang University, Hangzhou 310058,
Abstract: After reverse transcription， the integrase enzyme catalyzes incorporation of HIV-1 (human immunodeficiency virus type 1) cDNA into the host cell genome， which is called integration. Since integration is vital to viral replication， the inhibition of integrase will definitely show a promising access to anti-HIV chemotherapy. This paper reviews the structure and function of integrase， as well as the latest progress of researches focusing on the inhibitors of integrase.
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