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Calcium/Calcineurin Signal Transduction Pathway in Saccharomyces cerevisiae
Zhao Yunying, Jiang Linghuo*
The Key Laboratory of Industrial Biotechnology of the Ministry of Educatio and the National Engineering Laboratory for Cereal Fermentation Technology, School of Biotechnology, Jiangnan University, Wuxi 214122, China
Abstract: In the yeast Saccharomyces cerevisiae， Ca2+ signaling mediated by the Ca2+/calmodulin dependent phosphatase， calcineurin， is required for survival during environmental stress. In the response to mating pheromone， salt and other environmental stresses， Ca2+ normally enters the cytosol of yeast cells through two unknown transporters X and M or the Ca2+ channel， which is composed of Cch1 and Mid1. One role of the phosphatase under these conditions is to dephosphorylate the transcription factor Crz1 in the cytosol. Dephosphorylated Crz1 rapidly translocates from the cytosol to the nucleus， where Crz1 activates the transcription of target genes including the vacuolar pump gene PMC1 and the ER/Golgi calcium pump gene PMR1. Together with the vacuolar Ca2+/H+ Vcx1， Pmc1 and Pmr1 act to maintain the normal physiological calcium concentration between 50~200 nmol/L. This review addresses the recent research progress in the study of the yeast Ca2+/calcineurin signaling pathway.
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