Home > Browse Issues > Vol.35 No.10
Role of MicroRNA in Tumor Cell Glycometabolism
Yang Jie, Dong Zhuo, Yang Lihua, Gong Zhaohui*
School of Medicine, Ningbo University, Ningbo 315211, China
Abstract: Most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol， rather than by a comparatively low rate of glycolysis followed by oxidation of pyruvate in mitochondria as in most normal cells. Malignant， rapidly growing tumor cells typically have glycolytic rates up to 200 times higher than those of their normal tissues of origin even if oxygen is plentiful. MicroRNAs (miRNAs) are a class of non-coding RNAs that perform their function at the post transcriptional level. In recent years， the increasing evidences demonstrate that miRNAs are mainly involved in glycometabolism by inducing hypoxia， affecting glucose uptake， regulating key enzymes and lactate production in the glycometabolism process. Consequently， miRNAs play a crucial role in tumor cell glycometabolism.
CN
EN