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Effects of Different Factors on Transport of Trivalent Chromium in Caco-2 Cell Monolayers
Long-Ying Zha*, Hai-Ji Luo, Wan-Li Li
Department of Nutrition and Food Hygiene, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China
Abstract: In order to investigate the effects of various dietary factors on intestinal absorption of different forms of trivalent chromium， a human intestinal epithelial cell model Caco-2 in vitro cultured was used to study the effect of copper， iron， zinc， vitamin C， sucrose， sodium oxalate， EDTA and sodium citrate on transport of chromium chloride and chromium picolinate. The results showed that iron significantly decreased the transport amount of chromium picolinate and chromium chloride in Caco-2 cell monolayers (P<0.05). However， copper and zinc produced no significant effect on their transport amount (P>0.05). The transport amount of chromium picolinate was not affected by vitamin C， sucrose， sodium citrate， EDTA and sodium oxalate (P>0.05). However， the transport amount of chromium chloride was significantly increased by vitamin C and sodium oxalate (P<0.05)， and decreased by sucrose (P<0.05). These results indicated that transport of chromium chloride was more easily affected by various dietary factors than that of chromium picolinate.
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