Progress in the Studies of Circadian Clock Regulating Matabolism

Abstract: Circadian control of physiology and behavior is required for a healthy life. Accumulating evidence in epidemiological and genetic suggests that the disruption of circadian rhythm connects to metabolic disorders. Circadian rhythm is controlled by circadian clock constituted transcription-translation feedback loop. Circadian clock controls the cellular metabolic process by two means as followed. Firstly， circadian clock regulates the expression of enzymes that modulate the rate-limiting steps of metabolic pathways and those nuclear receptors in relation with metabolism; Secondly， circadian clock may interacts with nuclear receptor in metabolism as transcription co-regulators to activate or repress the expression of metabolic genes. Although circadian clock orchestrates multiple metabolic pathways resulting in the circadian oscillations of metabolites， the availability of metabolites can affect the expression of circadian clock in turn. A further study in the crosstalk of circadian clock and metabolic may provide new therapeutic strategy against metabolic disorders.

CSTR: 32200.14.cjcb.2013.10.0016