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Research Advances in Inflammasome
Wu Dan, Huang Zhiwei*
School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China
Abstract: Inflammasome， a kind of polyprotein complexes， can activate caspase-1， regulate interleukin 1β (IL-1beta) and IL-18 processing and mature， thereby inducing the body’s immune response. As the important regulatory factor of inflammation and cell death， inflammasome plays an important role in innate immunity and inflammatory disease development. In this review， we focus on the recent progress in the studies of the structure of inflammasome， mechanism of inflammation and related diseases and so on.
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