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Research Progress on the Function of Maf1 as A Negative Regulator of RNA Polymerase III in Yeast
Yan Hongbo1, Jiang Linghuo1,2*
1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China;2The National Engineering Laboratory for Cereal Fermentation Technology, School of Biotechnology, Jiangnan University, Wuxi 214122, China
Abstract: The tRNA biosynthesis is down-regulated by RNA polymerase III (Pol III) under growth-limiting conditions in budding yeast， Saccharomyces cerevisiae. This repression is mediated by Maf1， a negative regulator of Pol III transcription. Conserved from yeast to man， Maf1 was originally discovered in S. cerevisiae through a genetic approach. The phosphorylation status of Maf1 determines its subcellular localization and interaction with the Pol III complex. Several Maf1 kinases have been identified to be involved in Pol III control. Moreover， Maf1 indirectly affects tRNA maturation and decay. Here we summarize the current understanding of the mechanisms by which Maf1 mediates Pol III activity and tRNA biosynthesis in yeast.
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