Home > Browse Issues > Vol.35 No.9
The Progress of the Mechanism of Integrin Regulating Epidermal Stem Cell Proliferation and Differentiation
Li Baichuan1, Li Hongli2*
1The 1st Team of Cadet Brigade, the Third Military Medical University, Chongqing 400038, China;2Department of Histology and Embryology, the Third Military Medical University, Chongqing 400038, China
Abstract: The role of epidermal stem cells in the repair after damage is causing for people’s concern. The way of split and the proliferative activity of it are essential for the epithelization. It has been confirmed that the proliferation and differentiation of epidermal stem cells are influenced by the factors such as receptors and the microenvironment. Integrins are mainly distributed in the membrane of epidermal stem cells， which play the role on adhesion， mediate two-way information transferred， and regulate proliferation， migration and differentiation of epidermal stem cells. Besides， epidermal stem cells’ activity lower and the split way change caused by integrin abnormal expression is closely related to a variety of diseases. In this paper， the expression and distribution of integrins， the mechanism of integrins regulating proliferation and differentiation of epidermal stem cells and the relationship of integrins abnormally with disease in recent years are summarized.
CN
EN