Home > Browse Issues > Vol.35 No.9
Oncolytic Adenovirus as a Vector of Gene Therapy for Cancer Progression and Safety Evaluation
He Wanwan, Zhou Li, Liu Tao, Ruan Jiangxing, He Binxia, Li Arong, Wang Yigang*
Xin Yuan Institute of Medicine and Biotechnology, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China
Abstract: Adenovirus is one of the most promising gene vectors in gene transfer by the reason of susceptibility， wide host ranges， low toxicity， high capacity， non-integrated features and so on. Now it has been widely transformed into various types of oncolytic adenovirus in the study of cancer gene therapy. Oncolytic adenoviruses is one of the most popular avenues in the study of gene therapy， so its safety has become another focus. This review focuses on the overall research progress and biosafty evaluation of oncolytic adenoviruses as cancer gene therapy vectors.
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