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The Roles of Long Noncoding RNAs in the Occurrence of Digestive System Tumors
Shao Yongfu, Jiang Xiaoming, Zhu Mengying, Yang Fang, Lu Xuwen, Guo Junming*
Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology,Ningbo University School of Medicine, Ningbo 315211, China
Abstract: Long noncoding RNAs (LncRNAs) are noncoding RNA molecules greater than 200 nt in length. Recent studies have demonstrated that the dysregulated LncRNAs are closely related with human digestive system tumors. They are widely involved in the regulation of gene expression network in the forms of epigenetic，transcriptional and post-transcriptional levels. Besides， they are associated with the tumor development， invasion，metastasis and prognosis. Further study of the relationship between LncRNAs and digestive cancers and their pathophysiological mechanisms will bring new strategies to tumor prevention and treatment.
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