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The Role of Microglia and Microglia Kinin B1 Receptors (B1R) in Diabetic Pain Neuropathy
Yang Jiajia, Hong Yanguo*
College of Life Sciences, Fujian Normal University, Fuzhou 350108, China
Abstract: Diabetes melitus is frequently disease harming mankind healthines. Diabetic pain neuropathy (DPN) is a frequent complication of diabetes melitus. Studies showed that microglia play a critical role in the induction of diabetic pain neuropathy. Recently it has ben demonstrated that kinin B1 receptors (B1R) are induced in micr oglia in the spinal cord during diabetes and res ults in the act ivation and migration of micr oglia le adding to diabetic pain neuropathic. This review will summarize the contributions of microglia B1R to DPN.
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