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Research Progress of the Theory “Alzheimer's Disease Is A Type 3 Diabetes”
Jia Dan1, Liu Ting1, Chen Shuchao1, Wang Weiqi1, Quan Xiaoping1, Gao Bing2, Lu Xiuli1*
1School of Life Science, Liaoning University, Shenyang 110036, China;2School of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China
Abstract: Alzheimer’s disease (AD) is a main type of brain neuronal degenerative disease， characterized by neurodegeneration in neocortical regions of the brain. Although pathogenetic mechanisms of Alzheimer’s disease are not well understood. There are many acceptable hypotheses such as amyloid β (Aβ) theory and cholesterol theory.Within the continuously growing body of knowledge in this field， a new hypothesis of AD is emerging which suggestes AD is a nerve endocrine disease or “type 3 diabetes”. Many clinical and animal studies indicate that AD is associated with insulin resistance and insulin and insulin-like growth factor signaling in the brain. In the present review we discussed the relationships between the key factors of AD such as β amyloid， cholesterol， insulin-like growth factor， etc. and insulin resistance in the patient’s brain with AD.
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