Home > Browse Issues > Vol.35 No.8
Role of Interleukin-38 and Its Related Cytokines in Inflammation
Yuan Xianli, Li Mingcai*, Li Yan, Gao Xueming, Gao Qiaoyan
Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China
Abstract: Interleukin (IL)-38 is the most recently discovered cytokine， which is the tenth member of IL-1 cytokine family. IL-38 shares a high homology with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38 which is the partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokine IL-17 and IL-22. IL-38 also can inhibit the production of IL-8 which is induced by IL-36γ， thus inhibiting inflammatory response. This review will introduce the biological characteristics， receptor and signal pathway，biological activity of IL-38 and its related cytokines.
CN
EN