The Biological Functions of Integrin LFA-1 and Its Ligand ICAM-1 and the Related Diseases

Abstract: The binding of lymphocyte function-associated antigen-1 (LFA-1) to its major ligand intercellular adhesion molecule-1 (ICAM-1) can mediate cell-cell and cell-extracellular matrix adhesion， which plays an important role in immune response and inflammation. The combination of LFA-1 and ICAM-1 is involved in many kinds of physical processes， including T lymphocyte activation and clonal proliferation， the initiation of the immune synapse’ formation， and mediation lymphocyte trafficking. In addition， it is related to the occurrence and development of many diseases， such as rheumatoid arthritis， organ transplantation acute rejection， coronary heart disease，and psoriasis vulgaris. In this review， we introduced the biological functions of LFA-1 and ICAM-1 and several diseases that associated with their interaction.

CSTR: 32200.14.cjcb.2013.08.0020