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Research Progress in Generation of Mature Hepatocytes or Hepatocyte-like Cells by Different Ways and Strategies
Fan Jinyu1,2, Wang Yan1,2, Li Lili1,2, Xu Cunshuan1,2*
1Key Laboratory for Cell Differentiation Regulation, Xinxiang 453007, China;2College of Life Science,Henan Normal University, Xinxiang 453007, China
Abstract: Hepatocytes perform most of the liver’s functions and are very important for the cellular therapy of liver disease as well as in drug research and development. It is difficult for primary cultured hepatocytes to expand and maintain for a long period in vitro， so how to get a large number of mature， fully differentiated hepatocytes has always been regarded as one of the most important research problem. In this review， we are going to summarize the results and the latest research progress of derivation of mature hepatocytes or hepatocyte-like cells from liver stem cells， embryonic stem cells， adult progenitor or stem cells as well as other adult cells via different strategies，with the expectation of directions for future research.
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