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Progress in Microtubule Depolymerase MCAK
Zhang Liangyu, Yao Xuebiao*
Anhui Key Laboratory of Cellular Dynamics & Chemical Biology, University of Science and Technology of China,Hefei 230027, China
Abstract: The cellular function of microtubule depends on its closely regulated dynamics. In cells， microtubule dynamics is modulated by microtubule-associated proteins. MCAK (mitotic centromere-associated kinesin)， a key microtubule depolymerase， orchestrates faithful chromosome segregation in mitotic cells by regulating spindle microtubule dynamics. The microtubule depolymerase activity of MCAK is closely regulated by a variety of mitotic kinases. More and more data indicates that deregulation of MCAK is correlated with tumorigenesis.
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