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The Expression of ANXA1 between Deciduas and Villus in the First Trimester Pregnancy
Hong-Mei Li, Xue-Qin Liu, Qiu-Bo Yu, Yan-Ling Dong, Yu-Bin Ding, Ying-Xiong Wang, Jun-Lin He*
The Laboratory of Reproductive Biology, The School of Public Health, Chongqing Medical University, Chongqing 400016, China
Abstract: Differential expression of ANXA1 in villus and deciduas from the first trimester pregnancy was investigated by two-dimensional gel electrophoresis and image analysia. The result showed the expression of a protein spot (isoelectric point is about 6.6， molecular weight is about 38 kDa) decreased significantly in deciduas. This protein spot was identified as ANXA1 by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and database searching. Low level expression of ANXA1 was further comfirmed in deciduas by RT-PCR， Western blotting and immunohistochemistry. The observation suggested that ANXA1 might play an important role in regulation the invasion of trophoblast and placentation during the early pregnancy.
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