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MicroRNAs， Micro but with Macro Roles in Cell Fate Determining
Liao Baojian, Xue Yanting, Pan Guangjin, Pei Duanqing*
Chinese Academy of Sciences Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
Abstract: Reprogramming， differentiation and trans-differentiation hold great potential in regenerative medicine. In these cell fate transitions， miRNAs or miRNA clusters play vital roles by targeting related mRNAs to direct the post-transcriptional regulation. Herein， this review outlines the latest breakthoughs in following topics:miRNA profiling and cell lineage determining， miRNAs in regulating the pluripotency of embryonic stem cells，miRNAs in regulating reprogramming， differentiation and trans-differentiation. In addition， we highlight the dramatic progresses of miR-302-367 cluster in cell fate regulation， based on our studies of reprogramming and transdifferentiation to neural progenitor stem cells using this cluster.
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