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Regulatory Effects of PI3K Signaling on HPG Axis in Mammalians
Wang Fan, Xiao Kaizhuan, Lin Chaoqi, Wang Zhengchao*
Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China
Abstract: With the deepening study of the phosphoinositide-3 kinase (PI3K) signaling pathway， there has been breakthrough progress in the mammalian during recent years， especially in the regulation of PI3K signaling on mammalian hypothalamic-pituitary-gonadal (HPG) axis， which has become focus in the present research areas. The present article discussed the effects of several members of PI3K signaling on mammalian HPG axis， which included the upstream regulatory factors: estradiol and ER etc. and the downstream target protein: mTOR， which would help further resolve the molecular mechanism of the mammalian ovary function and provide some important reference for clinical applications.
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