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Regulatory Effects of NOS and NO/cGMP Signaling Pathway on Mammalian Follicular Development
Xu Mulin, Zheng Kaizhi, Sun Siyu, Shi Fangxiong*
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
Abstract: Nitric oxide is a multifunctional factor mediating multiple biological effects， especially in regulation of mammalian ovarian functions. Nitric oxide synthases (NOS) are key rate-limiting enzymes in NO synthesis and have three types: neuronal NOS (nNOS)， inducible NOS (iNOS) and endothelial NOS (eNOS). Recent studies showed that NOS and nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway had a great impact on mammalian follicular development. This article focuses on the effect and prospect of NOS and NO/cGMP signaling pathway on mammalian follicular development.
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