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Progress in Research of Polymorphism in MicroRNA Target Sites and Colorectal Cancer
Cui Jian1, Zhang Xiaoqing2, Yang Fangfang2, Yang Jin2*
1Clinical Medical Lab, Qinghai Hospital of Traditional Chinese Medicine, Qinghai 810000, China; 2College of Life Sciences, Northwest University, Xi’an 710069, China
Abstract: Overexpression and silencing of specific microRNA (miRNA) are associated with the development and progression of colorectal cancer (CRC). Recent studies have demonstrated that the regulation of miRNA is also influenced by the polymorphism in its target site， which is implicated in the pathobiology of various cancers. In this paper， we will review the potential role of polymorphisms in microRNA target sites as genetic markers for risk assessment of cancers， with an aim to offer new insight into the study of individual difference in CRC susceptibility and pharmacogenetics.
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