Home > Browse Issues > Vol.35 No.7
Recent Progress in Epigenetics Study of Colorectal Cancer
Chen Cheng1, Ye Meng2*, Duan Shiwei1, Liao Qi1
1School of Medicine, Ningbo University, Ningbo 315211, China; 2The Affiliated Hospital of Ningbo University, Ningbo 315000, China
Abstract: Colorectal cancer is one of the most common gastrointestinal cancers with high incidence and poor prognosis. It is generally considered that the pathophysiology of colorectal cancer is a complex multi-step process involving the accumulation of genetic and epigenetic changes. The main epigenetic aberrations include DNA methylation， histone modification， chromatin remodeling， and non-coding RNAs regulation such as microRNAs and long noncoding RNAs (lncRNAs). Epigenetic study at molecular level would help to prevent， diagnose， and therapy of colorectal cancer， and finally to reduce mortality. In this review， we will talk about discovered epigenetic changes of colorectal cancer and their clinical significance， aiming to explore the possibility of the early diagnosis and early treatment for colorectal cancer with epigenetic characters.
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