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Research Progress on Mechanism of High-mobility Group Protein 1(HMGB1)-mediated Autophagy
Sun Peng, Song Jinning*
Department of Neurosurgery, First Affiliated Hospital, Medical School of Xi’an Jiaotong University, Xi’an 710061, China
Abstract: Autophagy is recognized as “programmed cell survival”. Autophagy is also a catabolic process， which is critical to maintaining cellular homeostasis and responding to cytotoxic insult. High-mobility group protein 1 (HMGB1) is a classical damage associated pattern molecule. A lot of findings demonstrate that HMGB1 can promote inflammatory response and cell differentiation. But， recent studies have shown that the expression of HMGB1 has a significant impact on the level of autophagy. This review focuses on recent progress concerning the mechanism of HMGB1-mediated autophagy.
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