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Role of Ngn3 Gene and Its Transcriptional Regulatory Network in Pancreatic Endocrine Development and Function
Gao Yong1, Yu Ping2, Cai Tao3, Chen Xiang1*
1Rehabilitation Department, the 2nd Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China; 2The Institute of Genome Medicine of Wenzhou Medical College, Wenzhou 325027, China; 3Experimental Medicine Section
Abstract: Ngn3 (neurogenin 3) and its direct targets NeuroD1 (neurogenic differentiation 1)， Islet-1 (insulin gene enhancer binding protein-1)， INSM1 (insulinoma associated 1) are core ITFs (islet transcription factors) regulatory genes. Recent reports demonstrate that Ngn3 and its transcriptional regulatory network play an important role in embryonic pancreatic endocrine cell or islet development and insulin production and secretion， as well as reprogramming stem cells or non-β cells into insulin producing and secreting β cells. Further investigation of how Ngn3 and its network including INSM1/INSM2 (insulinoma associated 2) determine islet development and mature islet cell fate help to understand the causes， treatment and prevention of pancreatic endocrine disease like diabetes.Hence， we reviewed some recent progresses of Ngn3 and its transcriptional regulatory network studies.
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