Home > Browse Issues > Vol.35 No.7
Progress of Artificial MicroRNAs in Cancer Gene Therapy
Huang Xiaoming1, Chen Xiang1,2, Jia Zhenyu1*
1Zhejiang Academy of Medical Sciences, Hangzhou 310013, China; 2School of Laboratory Medicine and Life Science, Wenzhou Medical College, Wenzhou 325025, China
Abstract: microRNA is 22nt non-coding small RNA which can mediate post-transcriptional gene silencing via assembly into RNA-induced silence complex (RISC). MicroRNAs involve in regulation of cell growth， differentiation， apoptosis and relate to cancer development and progression. The biogenesis， functional mechanisms of microRNA， and its roles playing in tumors and miRNA-based cancer gene therapy are introduced in this review.
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