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Significance and Expressions of CEACAM6 and β-catenin in Colorectal Carcinomas
Wang Ye1, Zhang Zhiyong2*, Wu Chenpeng2, Zhang Lin2, Li Xuemei2, Feng Junwei3
1Department of Urinary Surgery, Tangshan Gongren Hospital, Tangshan 063000, China; 2Department of Pathology, Tangshan Gongren Hospital, Tangshan 063000, China; 3Department of Oncology Surgery, Tangshan Gongren Hospital, Tangshan 063000, China
Abstract: The expressions of CEACAM6 and β-catenin protein and mRNA in the primary tumours (n=228) and marginal mucosa samples (n=228) of colorectal carcinomas were examined by immunohistochemistry and Real-time PCR to provide experimental data for diagnosis and treatment of colorectal carcinomas. Furthermore， the relationship between the expressions of CEACAM6， β-catenin and the clinicopathological features was analyzed. The expressions of CEACAM6 protein and mRNA were increased in the primary tumours of colorectal carcinomas. The aberrant expressions of β-catenin protein and mRNA were also increased in the primary tumours of colorectal carcinomas. The expressions of CEACAM6 and β-catenin were correlated with lymph node metastasis and TNM stages. Positive correlation between CEACAM6 and β-catenin protein and mRNA were found in colorectal carcinoma. CEACAM6 and β-catenin might play an important role in the pathogenesis and progress of colorectal carcinoma. Combined detection of CEACAM6 and β-catenin could be helpful for diagnosis and treatment of colorectal carcinoma.
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