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Regulation and Function of Prostaglandins during Embryo Implantation and Decidualization
Weng-Bo Deng1, Zeng-Ming Yang1,2*
1College of Life Science, Northeast Agricultural University, Harbin 150030, China; 2College of Life Science, Xiamen University, Xiamen 361005, China
Abstract: Prostaglandins are essential for mammalian female reproduction. Cyclooxygenase-2 (COX-2)， which is mainly expressed in the stromal cells surrounding the implanting blastocyst， mediates the process of implantation and decidualization. Prostaglandin E2 derived from COX-2 and microsomal prostaglandin E synthase 1 is important for implantation and decidualization. Prostaglandin I2 from uterus plays a key role in embryo implantation via its nuclear receptor peroxisome proliferator-activated receptor δ. Prostaglandin transporter in cell membrane provides the growing requirement for prostaglandins during implantation and decidualization， and maintains the metabolic balance of prostaglandins.
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