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Research Progress in Cytotoxicity and Mechanism of Hexavalent Chromium
Jin Lifang, Yuan Yimeng, Hu Yirui, Ni Jian*
College of Life Science, Shaoxing Univisity, Shaoxing 312000, China
Abstract: The hexavalent chromium [Cr(VI)] is a common contaminant found in soil， air and water. It can be ingested via digestive tract， respiratory tract and skin contact， and directly or indirectly cause severe health problems in humans. This review summarizes the recent research progress in the effect and the mechanism of Cr(VI)-induced cytotoxicity， such as reactive oxygen species (ROS) accumulation， cell apoptosis， carcinogenesis， and so on. The future exploration of Cr(VI) cytotoxicity should focus on its molecular mechanisms at the genomic level.
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