Home > Browse Issues > Vol.30 No.3
Progress in Cardiac Stem or Progenitor Cells
Qing-Jian Han, Yao-Zhou Zhang*
Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China
Abstract: The discovery of cardiac stem or progenitor cells (CSC/CPCs) has not only provided us an optimal cell type for curing heart disease， but made us realize that adult heart of mammalian was a self-renewing organ as well. Recently， different subsets of CSC/CPCs have been identified， furthermore， the physiological microenvironment where they resided has been studied intensively. In this paper， we will firstly review the phenotype and differential potential of different subpopulation of CSC/CPCs， the molecular mechanism that regulates their quiescence， self-renewal， migration， or differentiation in vivo， the origin of CSC/CPCs， and then give a brief summary on the research of cardiomyocytes derived from embryonic stem cells (ESCs). After all， in this review， we hope to provide a meaningful clue for the clinical application of stem cells to cardiac disease.
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