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Role of IL-37b in Inflammation and Related Diseases
Gao Xueming, Li Mingcai*, Li Yan, Yuan Xianli, Gao Qiaoyan, Wang Yaqing
Department of Immunology, Medical School of Ningbo University, Ningbo 315211, China
Abstract: Inteleukin-1F7 (IL-1 family 7) is a novel member of the IL-1 family. It has been currently named as IL-37. IL-37 has five different subtypes (IL-37a-e). Recent studies found that IL-37b can be combined with α chain of the IL-18 receptor， but does not affect the physiological functions of the IL-18. Binding of IL-37b and IL-18BP (IL-18 binding protein) can enhance the suppression of IL-18BP on IL-18. Some reports showed that IL-37b has significant anti-inflammatory effects. IL-37b plays an important role in a variety of inflammation-related diseases.
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