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Implication and Prospect of AMPK in Translational Medical Research
Yang Zichu1*, Liao Junling2
1Department of Thoracic and Cardiovascular Surgery, the Second Affiliated Hospital, Kunming Medical University, Kunming 650101,China;2Center for Reproduction and Fertility, the Second Affiliated Hospital, Kunming Medical University,
Abstract: 5′-Adenosine monophosphate-activated protein kinase (AMPK) is an important enzyme in energy homeostasis. It is also a pivotal protein involved in many cellular signaling cascades. It is now considered as a key regulator not only in metabolic disorders but also in many other pathological conditions including cardiovascular disease and reproductive disorders. In addition， it plays a significant role in human malignancy. However， the property of AMPK in terms of clinical significance is not yet fully characterised. In this review， we covered current advances in AMPK research from the molecular basis to its clinical relevance. We also concluded that AMPK is a hot research spot in translational medicine. As a consequence， the outcome of AMPK research could be used as molecular therapeutic target in personalised medicine.
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