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Regulation of Stem Cell Pluripotency Maintenance and Cell Lineage Differentiation by Alternative Splicing
Liu Huan, Li Jie, Zhou Yue*
Department of Orthopedics, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China
Abstract: Alternative splicing is an important process of post-transcriptional modification. It provides
a good explanation for the significant difference between the limited number of genes and the protein diversity.
Several biological behaviors are regulated by alternative splicing， such as proliferation， differentiation and
development. As well as， the occurrence of many diseases are related with alternative splicing， including cancer.
The studies of stem cell pluripotency maintenance and cell lineage differentiation mostly focus on transcription
factors， chromatin remodeling， and non-coding RNA. Alternative splicing provides a new sight for stem cell study.
The text summarized newest researches on regulation of stem cell by alternative splicing. First alternative splicing
events were existed in different kinds of stem cells， including totipotent stem cells， pluripotent stem cells and
progenitor cells. Next， the regulation of stem cell by alternative splicing was elaborated from four aspects. Finally，
the splicing events during cell lineage differentiation of stem cells were summed up， including neural progenitor
differentiation， cardiac precursor differentiation， myogenic differentiation， adipocyte differentiation and bone
differentiation. All of these studies suggested that alternative splicing might play key roles in stem cell research in
the future.
a good explanation for the significant difference between the limited number of genes and the protein diversity.
Several biological behaviors are regulated by alternative splicing， such as proliferation， differentiation and
development. As well as， the occurrence of many diseases are related with alternative splicing， including cancer.
The studies of stem cell pluripotency maintenance and cell lineage differentiation mostly focus on transcription
factors， chromatin remodeling， and non-coding RNA. Alternative splicing provides a new sight for stem cell study.
The text summarized newest researches on regulation of stem cell by alternative splicing. First alternative splicing
events were existed in different kinds of stem cells， including totipotent stem cells， pluripotent stem cells and
progenitor cells. Next， the regulation of stem cell by alternative splicing was elaborated from four aspects. Finally，
the splicing events during cell lineage differentiation of stem cells were summed up， including neural progenitor
differentiation， cardiac precursor differentiation， myogenic differentiation， adipocyte differentiation and bone
differentiation. All of these studies suggested that alternative splicing might play key roles in stem cell research in
the future.
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