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Application of Cells Co-culture Technique in Bone Tissue Biology
Xie Li, Meng Rui, Shang Peng*
Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences,Northwestern Polytechnical University, Xi’an 710072, China
Abstract: Different bone cells constitutes a complex network structure， which transmit signals each other
via paracrine and gap junction channels and adjust bone modeling and remodeling. Cells co-culture technique is
the key method to investigate cell/cell interactions in vitro. Currently， this technique has two types: the contact coculture
and non-contact co-culture. For the bone tissue， since the importance of osteocyte in mechanical sensing
and in regulation of bone modeling and remodeling， it is important for the research of bone biology to establish
the suitable co-culture technique between osteocyte and other bone cells. This article is aimed at reviewing the
development of cells co-culture technique in the bone tissue biology.
via paracrine and gap junction channels and adjust bone modeling and remodeling. Cells co-culture technique is
the key method to investigate cell/cell interactions in vitro. Currently， this technique has two types: the contact coculture
and non-contact co-culture. For the bone tissue， since the importance of osteocyte in mechanical sensing
and in regulation of bone modeling and remodeling， it is important for the research of bone biology to establish
the suitable co-culture technique between osteocyte and other bone cells. This article is aimed at reviewing the
development of cells co-culture technique in the bone tissue biology.
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