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MicroRNA: A New Mechanism for Regulation of Mitochondrial Function
Wang Xuexiang, Song Yanrui, Li Shishi, Fan Mingjie, Yan Qingfeng*
College of Life Sciences, Zhejiang University, Hangzhou 310058, China
Abstract: Mitochondria are the energy powerhouse of the cell， and they play an important role in other
physiological and pathological process， such as free radical production， cell apoptosis and aging. MiRNA-mediated
post-transcriptional regulation of gene expression is one of the important mechanisms that regulate mitochondria
functions which rely on the crosstalk between nuclear genome and mitochondrial genome. The nuclear encoded
miRNA not only regulates the structure and function of mitochondria through modulating mitochondrial-related
proteins encoded by the nuclear genome， they can also translocate into the mitochondria and regulate mitochondrial
genome expression. Besides， the mitochondrial genome may also encode miRNA that could be immediately active
on the mitochondrial transcripts or exported in the cytosol in order to interfere with genomic mRNA.
physiological and pathological process， such as free radical production， cell apoptosis and aging. MiRNA-mediated
post-transcriptional regulation of gene expression is one of the important mechanisms that regulate mitochondria
functions which rely on the crosstalk between nuclear genome and mitochondrial genome. The nuclear encoded
miRNA not only regulates the structure and function of mitochondria through modulating mitochondrial-related
proteins encoded by the nuclear genome， they can also translocate into the mitochondria and regulate mitochondrial
genome expression. Besides， the mitochondrial genome may also encode miRNA that could be immediately active
on the mitochondrial transcripts or exported in the cytosol in order to interfere with genomic mRNA.
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