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PLA2 Subtypes and Their Relationships with Male Reproduction
Xie Haifeng2,1, Li Kun2, Ni Ya1,2*
1Unit of Reproductive Physiology, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China;
2School of Medical Lab Science, School of Life Sciences, Wenzhou Medical College, Wenzhou 325035, China
2School of Medical Lab Science, School of Life Sciences, Wenzhou Medical College, Wenzhou 325035, China
Abstract: Phospholipase A2 (PLA2)， which exists widespreadly in the mammalian， is one of the most
crucial enzymes that play important roles in cell metabolism， signal transduction and so forth. With the further
research of phospholipase A2， more than 30 enzymes that possess phospholipase A2 or related activity have been
identified in mammals and it helps to lead a new advance in revealing the male reproduction relevant phospholipase
A2 isozymes. This review focuses on the current understanding of the classification and characterization of
phospholipase A2 family members， the localizations of phospholipase A2s in male reproductive system， the roles of
phospholipase A2 and its signal transduction pathways in the acrosome reaction， phospholipase A2 subtypes relevant
to the male reproduction， etc. This article is a study on the roles and the mechanisms of phospholipase A2s in male
reproductive system which may provide a theoretical basis and thinking for a strategy in the male infertility diagnosis
and treatment.
crucial enzymes that play important roles in cell metabolism， signal transduction and so forth. With the further
research of phospholipase A2， more than 30 enzymes that possess phospholipase A2 or related activity have been
identified in mammals and it helps to lead a new advance in revealing the male reproduction relevant phospholipase
A2 isozymes. This review focuses on the current understanding of the classification and characterization of
phospholipase A2 family members， the localizations of phospholipase A2s in male reproductive system， the roles of
phospholipase A2 and its signal transduction pathways in the acrosome reaction， phospholipase A2 subtypes relevant
to the male reproduction， etc. This article is a study on the roles and the mechanisms of phospholipase A2s in male
reproductive system which may provide a theoretical basis and thinking for a strategy in the male infertility diagnosis
and treatment.
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