Home > Browse Issues > Vol.35 No.1
The Current Development in Extracellular Occurring DNA Study
Liu Jinghui, Wang Hao, Xu Lihong*
Department of Biochemistry, Medical School of Zhejiang University, Hangzhou 310058, China
Abstract: Extracellular occurring DNA (eoDNA) refers to the DNA presents in the extracellular environment
and is found in various extracellular media widely. The studies so far have suggested that quantitative and
qualitative changes of eoDNA might be used as markers for diagnosis and prognostic in clinical purpose. With the
development of biotechnology， the advantages in easy access， minimally invasive and early diagnostic value have
led to eoDNA becoming an attractive exploring area for developing a type of new less-invasive diagnostic and
prognostic biomarkers. The higher concentration of eoDNA in patients with malignancy than that in healthy individuals
has been proved widely. And it also seems that eoDNA in cancer patients has similar features with the DNA
from their tumor tissues， which provides the theory basis for eoDNA as a new marker for early detection of malignant
tumors. Besides， scientists have been developing non-invasive prenatal diagnostic tests based on cell-free fetal
DNA analysis from maternal plasma. In the present paper， the research obtained hitherto about eoDNA have been
reviewed and the perspective of eoDNA in the diagnosis of diseases are also discussed.
and is found in various extracellular media widely. The studies so far have suggested that quantitative and
qualitative changes of eoDNA might be used as markers for diagnosis and prognostic in clinical purpose. With the
development of biotechnology， the advantages in easy access， minimally invasive and early diagnostic value have
led to eoDNA becoming an attractive exploring area for developing a type of new less-invasive diagnostic and
prognostic biomarkers. The higher concentration of eoDNA in patients with malignancy than that in healthy individuals
has been proved widely. And it also seems that eoDNA in cancer patients has similar features with the DNA
from their tumor tissues， which provides the theory basis for eoDNA as a new marker for early detection of malignant
tumors. Besides， scientists have been developing non-invasive prenatal diagnostic tests based on cell-free fetal
DNA analysis from maternal plasma. In the present paper， the research obtained hitherto about eoDNA have been
reviewed and the perspective of eoDNA in the diagnosis of diseases are also discussed.
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